张雪莹
泰山学者青年专家（人才称号）
邮箱：zhangxueying@lcu.edu.cn
讲授课程
- 本科生课程《系统解剖学》
- 研究生课程《神经细胞生物学》
主要研究方向
代表性科研项目
- 山东省自然科学基金青年项目：坐骨神经源性外泌体激活海马dsRNA-TLR3信号通路介导慢性神经病理性疼痛并发认知障碍的机制研究，2025
- 国家自然科学基金青年项目：施万细胞来源外泌体携带dsDNA激活海马STING通路调控慢性神经病理性疼痛并发认知障碍的机制研究，2025
代表性论文
1.Xueying Zhang, Rui Gao,Tao Zhu and Chan Chen. Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice. Signal Transduction and Targeted Therapy (2023)8:292 (IF：40.8）
2.Xueying Zhang, Rui Gao, Changteng Zhang, Hai Chen, Ruiqun Wang, Qi Zhao,Tao Zhu and Chan Chen. Evidence for Cognitive Decline inChronic Pain: A Systematic Review and Meta-Analysis Front. Neurosci. 15:737874.(IF:4.6）
3.Xueying Zhang, Yongxin Liang, Nannan Zhang, Ying Yan, Shanling Liu, Hao Fengxi, Dai Zhao, and Haichen Chu. The Relevance of the OPRM1 118A>G Genetic Variant for Opioid Requirement in Pain Treatment: A Meta-Analysis [J]. Pain physician, 2019, 22(4): 331-340. (IF:4.3)
4.Xueying Zhang, Yongxin Liang, Ying Yan, Zhao Dai, Haichen Chu. Morphine: double-faced roles in the regulation of tumor development[J]. Clinical and Translational Oncology, 2018, 20(7): 808-814.（IF:3.1)
5.张雪莹，梁永新，温翠丽，夏婧，褚海辰. ABCB1 C3435T 基因多态性对患者术后镇痛效果的影响[J]. 中华麻醉学杂志， 2019，39（9）：1085-1087.
6.Tang Y, Liu C, Zhu T, Chen H, Sun Y, Zhang XY, Zhao Q, Wu J, Fei X, Ye S, Chen C. Transcriptome Profiles of IncRNA and mRNA Highlight the Role of Ferroptosis in Chronic Neuropathic Pain With Memory Impairment. Front Cell Dev Biol. 2022 Apr 25;10:843297.
7.Cai X, Gao R, Wang R, Zhang XY, Chen C. Dexmedetomidine and Lidocaine: Useful Adjuvants for Analgesia after Abdominal Surgery? Pain Physician. 2022 Mar;25(2):E399-E401.
8.Zhao Q, Gao R, Liu C, Chen H, Zhang XY, Guan J, Xie X, Qiu Y, Cheng X, Lv P, Zhu T, Chen C. Dynamic Change of Lymphocyte-to-Monocyte Is Associated With the Occurrence of POCD After Cardiovascular Surgery: A Prospective Observational Study. Front Behav Neurosci. 2021 Apr 13;15:646528.
9.Xie X, Gao R, Chen H, Zhang XY, Cai X, Zhang C, Liu C, Zhu T, Chen C. Effects of Glucocorticoids on Postoperative Neurocognitive Disorders in Adult Patients: A Systematic Review and Meta-Analysis. Front Aging Neurosci. 2022 Jun 30;14:939848. doi: 10.3389/fnagi.2022.939848.
10.Liu C, Zhao Z, Gao R, Zhang XY, Sun Y, Wu J, Liu J, Chen C. Matrix Metalloproteinase-2-Responsive Surface-Changeable Liposomes Decorated by Multifunctional Peptides to Overcome the Drug Resistance of Triple-Negative Breast Cancer through Enhanced Targeting and Penetrability. ACS Biomater Sci Eng. 2022 Jul 11;8(7):2979-2994.
11.Wang R, Gao R, Xie X, Chen H, Zhao Q, Zhang XY, Zhang C, Deng L, Lv P, Zheng Q, Zhu T, Chen C. Perioperative platelet count in peripheral blood is associated with the early stage of PND after major orthopedic surgery: a prospective observational study. BMC Geriatr. 2022 Mar 14;22(1):200.
12.Liu C, Gao R, Tang Y, Chen H, Zhang XY, Sun Y, Zhao Q, Lv P, Wang H, Ye-Lehmann S, Liu J, Chen C. Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve. Front Neurosci. 2022 Aug 18;16:925300.
